![Dalle sostanze chimiche ai prodotti farmaceutici](/sites/default/files/styles/hero_small/public/modules/hero/images/hero2.jpg?itok=kTfFBRbZ)
From chemicals to pharmaceuticals
Zach System
Manufacturing
![Avrillé](/sites/default/files/styles/imgdxsin_small/public/modules/imgdxsin/images/Avrille%CC%801.jpg?itok=fjQVCMNA)
Zach Avrillé site
Zach Avrillé site has a long tradition in process development & API/ pharmaceutical intermediates manufacturing.
- 210 employees (23 in R & D)
- Long-term experience with the main regulatory authorities (FDA, local authorities, PMDA, K-FDA)
- Complete regulatory support (DMF, IMPD)
- 215MT of APIs and GMP intermediates manufactured each year
- Approximately 6000 samples analyzed each year in CQ
- 70% of the activity is concentrated in the Custom Manufacturing sector
- 5-10 new projects / products developed each year
- Manipulation of HPAPI with OEL> 1 μg / m3 (OEB 4) on an industrial scale
- Continuous investments (new laboratory confined for the handling of HPAPI, filter dryer in Hastelloy, Pin Mill, Revamping R&D Laboratory, warehouse extension)
- Project Management Approach
Our numbers
![Avrillé/ Francia](/sites/default/files/styles/infographic_xlarge/public/modules/infographic/images/avrille_infografica%202_0.png?itok=5QpfwlET)
API
Our finishing equipments are located in clean rooms (ISO8) fed with purified / low pyrogen water
Isolation & Drying
- Filter Dryer
- Press filter
- Centrifuge
- Tumble dryers
- Pan dryers
- Tray dryer
- Freeze dryer
- Spray dryer (PSD1 & PSD2)
Particle size reduction
- Pin mill under nitrogen
- Hammer mill under nitrogen
- Jet mill (200 & 300)
Class of products
- Classical APIs made in multipurpose equipments
- High potent APIs having an OEL> 1 µg/m3 (OEB 4) including corticosteroids at industrial scale
- High Purity Low Endotoxins EXCIPIENTS
The assurance of cutting-edge plants
![](/sites/default/files/styles/statementimg_small/public/2018-05/Avrille%CC%804.jpg?h=fee4874d&itok=Cdw0EdfD)
Zach System's customer commitment offers the assurance of cost-effective solutions able to provide full support during every phase of small-scale production, from pilot to industrial synthesis.